Pestalotilide A, a New Cytotoxic Diphenyl Ether Derivative from Pestalotiposis guepinii

A new diphenyl ether derivative, named pestalotilide A (1), along with four known compounds (2-5) have been isolated from the organic extracts of an endophytic fungus Pestalotiposis guepinii. Their structures were elucidated on the basis of HR-ESI-MS, 1D and 2D NMR spectroscopic data analyses. These...

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Bibliographic Details
Published in:Natural product communications 2018-06, Vol.13 (6)
Main Authors: Xiao, Jian, Zhong, Wan-Tong, Lin, Li-Bin, Zhao, Xiang, Shi, Wei, Hu, Jia-Yao, Duan, Dong-Zhu, Wang, Le, Wang, Xiao-Ling
Format: Article
Language:English
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Summary:A new diphenyl ether derivative, named pestalotilide A (1), along with four known compounds (2-5) have been isolated from the organic extracts of an endophytic fungus Pestalotiposis guepinii. Their structures were elucidated on the basis of HR-ESI-MS, 1D and 2D NMR spectroscopic data analyses. These isolates were evaluated for cytotoxicity against three cancer cell lines: Hela, HCT116 and A549; pestalotilide A exhibited weak in vitro anti-proliferative activities against the tested cell lines, with IC50 values of 23.8, 18.4 and 35.2 μM, respectively.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1801300621