Rhabdaprovidines D–G, Four New 6,6,5-Tricyclic Terpenoids from the Vietnamese Sponge Rhabdastrella providentiae

Four new 6,6,5-tricyclic terpenoids, named rhabdaprovidines D-G (1–4), were isolated from the Vietnamese sponge Rhabdastrella providentiae. The structures of 1–4 were elucidated by extensive analysis of HR-ESI-MS and NMR spectroscopy. The absolute stereochemistry of compounds 3 and 4 were determined...

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Bibliographic Details
Published in:Natural product communications 2018-10, Vol.13 (10)
Main Authors: Dung, Duong Thi, Hang, Dan Thi Thuy, Nhiem, Nguyen Xuan, Quang, Tran Hong, Tai, Bui Huu, Yen, Pham Hai, Hoai, Nguyen Thi, Thung, Do Cong, Van Minh, Chau, Van Kiem, Phan
Format: Article
Language:English
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Summary:Four new 6,6,5-tricyclic terpenoids, named rhabdaprovidines D-G (1–4), were isolated from the Vietnamese sponge Rhabdastrella providentiae. The structures of 1–4 were elucidated by extensive analysis of HR-ESI-MS and NMR spectroscopy. The absolute stereochemistry of compounds 3 and 4 were determined by both experimental and theoretical calculated circular dichroism (CD) spectra. Compounds 1, 2, and 4 contained trans-syn-trans 6,6,5-tricyclic nucleus meanwhile compound 3 possessed trans-syn-cis ring junction. Compound 4 displayed novel structure by the presence of five rings and nine chiral carbon centers in the isomalabaricane triterpene backbone.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1801301004