Alkaloids From Zanthoxylum nitidum and Their Cytotoxic Activity

Zanthoxylum nitidum (Roxb.) DC (Rutaceae) is a traditional medicine used for the treatment of various diseases like toothache, gingivitis, fever, colic vomiting, diarrhea, and cholera. Three new alkaloids, zanthocadinanine C (1), 7-methoxy-8-demethoxynitidine (2), and zanthonitiside I (3) were isola...

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Bibliographic Details
Published in:Natural product communications 2019-05, Vol.14 (5)
Main Authors: Nguyen, Thi Hong Van, Tran, Thi Tuyen, Cam, Thi Inh, Pham, Minh Quan, Pham, Quoc Long, Vu, Dinh Hoang, Nguyen, Xuan Nhiem, Chau, Van Minh, Van, Kiem Phan
Format: Article
Language:English
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Summary:Zanthoxylum nitidum (Roxb.) DC (Rutaceae) is a traditional medicine used for the treatment of various diseases like toothache, gingivitis, fever, colic vomiting, diarrhea, and cholera. Three new alkaloids, zanthocadinanine C (1), 7-methoxy-8-demethoxynitidine (2), and zanthonitiside I (3) were isolated from the stems and twigs of Z. nitidum. Their structures were determined on the basis of extensive spectroscopic, including 1-dimensional and 2-dimensional nuclear magnetic resonance and mass spectroscopy data. Compounds 1–3 were evaluated for cytotoxic activity against 5 human cancer cell lines, KB, MCF-7, LNCaP, HepG-2, and LU-1. Compound 2 showed significant cytotoxic activity against all tested human cancer cell lines with IC50 values ranging from 10.3 to 12.6 µM.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X19844133