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Phytochemicals of Gandarusa (Justicia gendarussa) and Its Preparations
Thirty-five metabolites of Justicia gendarussa (JG) leaves and its preparations were identified using LC-HR-MS/MS. Although alkaloids were detected in the leaves they were not identified in JG preparations using Smart Formula 3D software. This showed that an acidified extraction process used at the...
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Published in: | Natural product communications 2019-06, Vol.14 (6) |
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container_title | Natural product communications |
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creator | Made Ratih, Gusti Ayu Imawati, Maria Fatmadewi Nugroho, Rendra Rizki Purwanti, Diah Intan Wongso, Suwidji Prajogo, Bambang Indrayanto, Gunawan |
description | Thirty-five metabolites of Justicia gendarussa (JG) leaves and its preparations were identified using LC-HR-MS/MS. Although alkaloids were detected in the leaves they were not identified in JG preparations using Smart Formula 3D software. This showed that an acidified extraction process used at the first stage of the purification procedure is able to remove the toxic alkaloids from the crude drug. The LC-MS/MS analyses showed that the main components of JG preparations were fatty acids and apigenin glycosides; it seemed that the fatty acids can be used for enhancing the dissolution of the polar glycosides. T-test calculation using Profile Analysis software showed that the acidified crude drugs, extract, granules of JG, and gendarussa capsules showed very similar LC-MS/MS profiles, which means that the biochemical components of JG are relatively stable during processing. Due to the lack of quality markers for these JG preparations, the application of metabolite profiling is recommended as the QC tool for commercial production by the pharmaceutical industry. |
doi_str_mv | 10.1177/1934578X19851406 |
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Although alkaloids were detected in the leaves they were not identified in JG preparations using Smart Formula 3D software. This showed that an acidified extraction process used at the first stage of the purification procedure is able to remove the toxic alkaloids from the crude drug. The LC-MS/MS analyses showed that the main components of JG preparations were fatty acids and apigenin glycosides; it seemed that the fatty acids can be used for enhancing the dissolution of the polar glycosides. T-test calculation using Profile Analysis software showed that the acidified crude drugs, extract, granules of JG, and gendarussa capsules showed very similar LC-MS/MS profiles, which means that the biochemical components of JG are relatively stable during processing. 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title | Phytochemicals of Gandarusa (Justicia gendarussa) and Its Preparations |
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