Limonoids From Choerospondias axillaris

Eight limonoids (1-8), including 1 new compound named as axillariol A (1), were isolated from the dichloromethane extract of Choerospondias axillaris branches and leaves using various chromatographic separations. Their structures were confirmed by detailed analysis of the 1-dimensional (1D), 2D nucl...

Full description

Saved in:
Bibliographic Details
Published in:Natural product communications 2020-08, Vol.15 (8)
Main Authors: Phan, Nguyen Huu Toan, Thuan, Nguyen Thi Dieu, Hien, Nguyen Thi Thu, Huyen, Pham Van, Hanh, Tran Thi Hong, Vien, Le Thi, Hong Quang, Tran, Cuong, Nguyen Xuan, Nam, Nguyen Hoai, Van Kiem, Phan, Van Minh, Chau
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Eight limonoids (1-8), including 1 new compound named as axillariol A (1), were isolated from the dichloromethane extract of Choerospondias axillaris branches and leaves using various chromatographic separations. Their structures were confirmed by detailed analysis of the 1-dimensional (1D), 2D nuclear magnetic resonance, and high-resolution electrospray ionization quadrupole time-of-flight mass spectra. In addition, toonaciliatins N (6) and toonaciliatins O (7) showed selective and significant cytotoxicity on the rhabdomyosarcoma human cancer cell line with half-maximal inhibitory concentration values of 9.12 and 7.79 µM, respectively.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X20948368