Identification of Cytotoxic Constituents from the Whole Plant of Isodon ternifolius

A new oxygenated spiroketone, isodonspiroketone (1), and 4 known ones (2-5) were isolated from the whole plant of Isodon ternifolius (D.Don) Kudô. The structure of isodonspiroketone (1) was determined by nuclear magnetic resonance, mass spectroscopy, and circular dichroism spectral data. Compound 3...

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Published in:Natural product communications 2020-09, Vol.15 (9)
Main Authors: Pham, Minh Quan, Le, Thi-Thuy-Huong, Do, Tien-Lam, Pham, Thi-Hong-Minh, Pham, Quoc-Long, Nguyen, Phi-Hung, To, Dao-Cuong
Format: Article
Language:English
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Summary:A new oxygenated spiroketone, isodonspiroketone (1), and 4 known ones (2-5) were isolated from the whole plant of Isodon ternifolius (D.Don) Kudô. The structure of isodonspiroketone (1) was determined by nuclear magnetic resonance, mass spectroscopy, and circular dichroism spectral data. Compound 3 has not been previously isolated from I. ternifolius. Their cytotoxic activities were evaluated against A549, HepG2, and MDA-MB-231 cancer cell lines in vitro. New compound (isodonspiroketone, 1) showed moderate cytotoxic activities against A549, HepG2, and MDA-MB-231 cancer cell lines with half-maximal inhibitory concentration values of 23.84 ± 2.73, 27.77 ± 3.01, and 17.26 ± 1.61 μM, respectively; meanwhile, the others were inactive.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X20953243