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A New Phenylethanoid Glycoside From the Leaves of Rosmarinus officinalis With Nitric Oxide Inhibitory Activity

A new phenylethanoid glycoside, named rosmacinalis (1), and 6x known compounds {2-phenylethyl O-α-L-rhamnopyranosyl-(1‴→6″)-O-β-D-glucopyranoside (2), clinopodiolide C (3), rosmanol (4), 7α-methoxyrosmanol (5) 7β-methoxyrosmanol (6) and carnosol (7)} were isolated from the leaves of Rosmarinus offic...

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Bibliographic Details
Published in:Natural product communications 2020-10, Vol.15 (10)
Main Authors: Huyen, Le Thi, Oanh, Le Thi, Son, Nguyen Thi, Thu, Nguyen Thi Minh, Hoang, Nguyen Huy, Yen, Pham Hai, Nhiem, Nguyen Xuan, Huu Tai, Bui, Kiem, Phan Van
Format: Article
Language:English
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Summary:A new phenylethanoid glycoside, named rosmacinalis (1), and 6x known compounds {2-phenylethyl O-α-L-rhamnopyranosyl-(1‴→6″)-O-β-D-glucopyranoside (2), clinopodiolide C (3), rosmanol (4), 7α-methoxyrosmanol (5) 7β-methoxyrosmanol (6) and carnosol (7)} were isolated from the leaves of Rosmarinus officinalis. Their structures were determined by extensive analysis of high-resolution electron spray ionization mass spectrum and nuclear magnetic resonance spectral data, as well as by comparison of the spectral data with those reported in the literature. Anti-inflammatory activity of compounds 1‐7 was evaluated by their inhibition of NO production in lipopolysaccharide-stimulated RAW 264.7 cells. At a concentration of 100 µM, compounds 1 and 2 exhibited inhibitory rates of 47.1% ± 2.2% and 44.5% ± 1.3%, respectively, while compounds 3‐7 showed a cytotoxic effect. After dilution to a concentration of 20 µM, except compound 7, compounds 1‐6 did not show a cytotoxic effect. Their NO inhibitory rates ranged from 14.2% ± 1.3% to 31.1% ± 1.9%.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X20969088