Heptacyclosordarianone, a New Polyketide From Sordaria sp., an Endophytic Fungus From Garcinia polyantha

One new polyketide derivative, heptacyclosordarianone (1), together with 2 known compounds, heptacyclosordariolone (2) and sordariol (3), were isolated from an extract of Sordaria sp. AM-71, an endophytic fungus inhabiting Garcinia polyantha. The structures of these compounds were elucidated based o...

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Bibliographic Details
Published in:Natural product communications 2020-12, Vol.15 (12)
Main Authors: Tsague Tankeu, Virginie Flaure, Sema, Denis Kehdinga, Jouda, Jean-Bosco, Tatsimo, Simplice Joel N., Ntonga, Patrick Akono, Wansi, Jean Duplex, Fogue, Simeon Kouam, Loura, Benoît, Shiono, Yoshihito, Sewald, Norbert, Lannang, Alain Meli
Format: Article
Language:English
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Summary:One new polyketide derivative, heptacyclosordarianone (1), together with 2 known compounds, heptacyclosordariolone (2) and sordariol (3), were isolated from an extract of Sordaria sp. AM-71, an endophytic fungus inhabiting Garcinia polyantha. The structures of these compounds were elucidated based on intensive nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry and by comparison with literature data. All compounds were assayed for their antimicrobial and cytotoxic properties. Only compound 2 showed antimicrobial activities against Bacillus subtilis DSMZ 704, Pseudomonas agarici DSMZ 11810, and Micrococcus luteus DSMZ 1605 with minimum inhibitory concentration values of 9.3, 15.5, and 16.9 µg/mL respectively. None of the isolated compounds showed a significant cytotoxic property.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X20977622