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Effects of body fat components on early renal functions of individuals following kidney donation
Objective: Obesity stands as a risk factor for the chronic kidney disease. The objective of this study was to investigate the relationship between early renal function following kidney donation and the measurements of body fat components. Methods: In total, 86 donors followed up for at least 6 month...
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| Published in: | Journal of clinical urology 2024-11, Vol.17 (6), p.600-606 |
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| Main Authors: | , |
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| Language: | English |
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| container_end_page | 606 |
| container_issue | 6 |
| container_start_page | 600 |
| container_title | Journal of clinical urology |
| container_volume | 17 |
| creator | Yığman, Metin Tangal, Semih |
| description | Objective:
Obesity stands as a risk factor for the chronic kidney disease. The objective of this study was to investigate the relationship between early renal function following kidney donation and the measurements of body fat components.
Methods:
In total, 86 donors followed up for at least 6 months postoperatively were included. Height and weight measurements and results of laboratory analysis of all donors were recorded retrospectively. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), hepatic fat (HF), pancreatic fat (PF) and splenic fat (SF) measurements were performed, and pancreatic splenic fat fraction difference (P−S) and pancreatic splenic fat fraction ratio (P/S) were calculated by a radiologist using the records of preoperative computed tomography scans of donors.
Results:
The estimated glomerular filtration rate (eGFR), serum creatinine and spot urinary microalbumin/creatinine ratio values of the donors at the sixth month postoperatively were statistically different from those of the preoperative values (p < 0.001). In addition, the individuals were divided into two categories based on the postoperative eGFR: ⩾ 60 mL/min/1.73 m2 and < 60 mL/min/1.73 m2. Age, low-density lipoprotein (LDL) level and VAT/SAT ratio were lower in group eGFR: ⩾ 60 (p < 0.001, p = 0.03, p = 0.007, respectively). Age and VAT/SAT ratio were the parameters found to be affecting the eGFR significantly, and VAT/SAT ratio (0.729, 95% CI: 0.602–0.856, p = 0.007) had higher predictive value in receiver operating characteristic curve (ROC).
Conclusion:
Preoperative measurements of body fat components may provide significant information to predict postoperative renal functions of kidney donor candidates.
Level of evidence:
Not applicable. |
| doi_str_mv | 10.1177/20514158221109411 |
| format | article |
| fullrecord | <record><control><sourceid>sage_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1177_20514158221109411</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_20514158221109411</sage_id><sourcerecordid>10.1177_20514158221109411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c166t-31bbaed1123f4f7010725f916229a389988acffa844f870efa89bb39345e12c83</originalsourceid><addsrcrecordid>eNp9kM1OwzAQhC0EElXpA3DzC6R4baexj6gqP1IlLnAOjuOtDKld2Skob09CERckTjsafbPaHUKugS0BquqGsxIklIpzAKYlwBmZTV4hYbU6_9WluiSLnH3DSiE0cMVm5HWD6GyfaUTaxHagaHpq4_4QgwuTHagzqRtocsF0FI_B9j6Gb96H1n_49mi6TDF2Xfz0YUfffRvcQNsYzERekQscAbf4mXPycrd5Xj8U26f7x_XttrDjjX0hoGmMawG4QIkVA1bxEjWsONdGKK2VMhbRKClRVcyNSjeN0EKWDrhVYk7gtNemmHNyWB-S35s01MDqqaX6T0tjZnnKZLNz9Vs8pvHH_E_gC5-PaA0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Effects of body fat components on early renal functions of individuals following kidney donation</title><source>Sage Journals Online</source><creator>Yığman, Metin ; Tangal, Semih</creator><creatorcontrib>Yığman, Metin ; Tangal, Semih</creatorcontrib><description>Objective:
Obesity stands as a risk factor for the chronic kidney disease. The objective of this study was to investigate the relationship between early renal function following kidney donation and the measurements of body fat components.
Methods:
In total, 86 donors followed up for at least 6 months postoperatively were included. Height and weight measurements and results of laboratory analysis of all donors were recorded retrospectively. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), hepatic fat (HF), pancreatic fat (PF) and splenic fat (SF) measurements were performed, and pancreatic splenic fat fraction difference (P−S) and pancreatic splenic fat fraction ratio (P/S) were calculated by a radiologist using the records of preoperative computed tomography scans of donors.
Results:
The estimated glomerular filtration rate (eGFR), serum creatinine and spot urinary microalbumin/creatinine ratio values of the donors at the sixth month postoperatively were statistically different from those of the preoperative values (p < 0.001). In addition, the individuals were divided into two categories based on the postoperative eGFR: ⩾ 60 mL/min/1.73 m2 and < 60 mL/min/1.73 m2. Age, low-density lipoprotein (LDL) level and VAT/SAT ratio were lower in group eGFR: ⩾ 60 (p < 0.001, p = 0.03, p = 0.007, respectively). Age and VAT/SAT ratio were the parameters found to be affecting the eGFR significantly, and VAT/SAT ratio (0.729, 95% CI: 0.602–0.856, p = 0.007) had higher predictive value in receiver operating characteristic curve (ROC).
Conclusion:
Preoperative measurements of body fat components may provide significant information to predict postoperative renal functions of kidney donor candidates.
Level of evidence:
Not applicable.</description><identifier>ISSN: 2051-4158</identifier><identifier>EISSN: 2051-4166</identifier><identifier>DOI: 10.1177/20514158221109411</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><ispartof>Journal of clinical urology, 2024-11, Vol.17 (6), p.600-606</ispartof><rights>British Association of Urological Surgeons 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c166t-31bbaed1123f4f7010725f916229a389988acffa844f870efa89bb39345e12c83</cites><orcidid>0000-0003-1217-8458</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79364</link.rule.ids></links><search><creatorcontrib>Yığman, Metin</creatorcontrib><creatorcontrib>Tangal, Semih</creatorcontrib><title>Effects of body fat components on early renal functions of individuals following kidney donation</title><title>Journal of clinical urology</title><description>Objective:
Obesity stands as a risk factor for the chronic kidney disease. The objective of this study was to investigate the relationship between early renal function following kidney donation and the measurements of body fat components.
Methods:
In total, 86 donors followed up for at least 6 months postoperatively were included. Height and weight measurements and results of laboratory analysis of all donors were recorded retrospectively. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), hepatic fat (HF), pancreatic fat (PF) and splenic fat (SF) measurements were performed, and pancreatic splenic fat fraction difference (P−S) and pancreatic splenic fat fraction ratio (P/S) were calculated by a radiologist using the records of preoperative computed tomography scans of donors.
Results:
The estimated glomerular filtration rate (eGFR), serum creatinine and spot urinary microalbumin/creatinine ratio values of the donors at the sixth month postoperatively were statistically different from those of the preoperative values (p < 0.001). In addition, the individuals were divided into two categories based on the postoperative eGFR: ⩾ 60 mL/min/1.73 m2 and < 60 mL/min/1.73 m2. Age, low-density lipoprotein (LDL) level and VAT/SAT ratio were lower in group eGFR: ⩾ 60 (p < 0.001, p = 0.03, p = 0.007, respectively). Age and VAT/SAT ratio were the parameters found to be affecting the eGFR significantly, and VAT/SAT ratio (0.729, 95% CI: 0.602–0.856, p = 0.007) had higher predictive value in receiver operating characteristic curve (ROC).
Conclusion:
Preoperative measurements of body fat components may provide significant information to predict postoperative renal functions of kidney donor candidates.
Level of evidence:
Not applicable.</description><issn>2051-4158</issn><issn>2051-4166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kM1OwzAQhC0EElXpA3DzC6R4baexj6gqP1IlLnAOjuOtDKld2Skob09CERckTjsafbPaHUKugS0BquqGsxIklIpzAKYlwBmZTV4hYbU6_9WluiSLnH3DSiE0cMVm5HWD6GyfaUTaxHagaHpq4_4QgwuTHagzqRtocsF0FI_B9j6Gb96H1n_49mi6TDF2Xfz0YUfffRvcQNsYzERekQscAbf4mXPycrd5Xj8U26f7x_XttrDjjX0hoGmMawG4QIkVA1bxEjWsONdGKK2VMhbRKClRVcyNSjeN0EKWDrhVYk7gtNemmHNyWB-S35s01MDqqaX6T0tjZnnKZLNz9Vs8pvHH_E_gC5-PaA0</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Yığman, Metin</creator><creator>Tangal, Semih</creator><general>SAGE Publications</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-1217-8458</orcidid></search><sort><creationdate>202411</creationdate><title>Effects of body fat components on early renal functions of individuals following kidney donation</title><author>Yığman, Metin ; Tangal, Semih</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c166t-31bbaed1123f4f7010725f916229a389988acffa844f870efa89bb39345e12c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yığman, Metin</creatorcontrib><creatorcontrib>Tangal, Semih</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of clinical urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yığman, Metin</au><au>Tangal, Semih</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of body fat components on early renal functions of individuals following kidney donation</atitle><jtitle>Journal of clinical urology</jtitle><date>2024-11</date><risdate>2024</risdate><volume>17</volume><issue>6</issue><spage>600</spage><epage>606</epage><pages>600-606</pages><issn>2051-4158</issn><eissn>2051-4166</eissn><abstract>Objective:
Obesity stands as a risk factor for the chronic kidney disease. The objective of this study was to investigate the relationship between early renal function following kidney donation and the measurements of body fat components.
Methods:
In total, 86 donors followed up for at least 6 months postoperatively were included. Height and weight measurements and results of laboratory analysis of all donors were recorded retrospectively. Visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), hepatic fat (HF), pancreatic fat (PF) and splenic fat (SF) measurements were performed, and pancreatic splenic fat fraction difference (P−S) and pancreatic splenic fat fraction ratio (P/S) were calculated by a radiologist using the records of preoperative computed tomography scans of donors.
Results:
The estimated glomerular filtration rate (eGFR), serum creatinine and spot urinary microalbumin/creatinine ratio values of the donors at the sixth month postoperatively were statistically different from those of the preoperative values (p < 0.001). In addition, the individuals were divided into two categories based on the postoperative eGFR: ⩾ 60 mL/min/1.73 m2 and < 60 mL/min/1.73 m2. Age, low-density lipoprotein (LDL) level and VAT/SAT ratio were lower in group eGFR: ⩾ 60 (p < 0.001, p = 0.03, p = 0.007, respectively). Age and VAT/SAT ratio were the parameters found to be affecting the eGFR significantly, and VAT/SAT ratio (0.729, 95% CI: 0.602–0.856, p = 0.007) had higher predictive value in receiver operating characteristic curve (ROC).
Conclusion:
Preoperative measurements of body fat components may provide significant information to predict postoperative renal functions of kidney donor candidates.
Level of evidence:
Not applicable.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><doi>10.1177/20514158221109411</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1217-8458</orcidid></addata></record> |
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| issn | 2051-4158 2051-4166 |
| language | eng |
| recordid | cdi_crossref_primary_10_1177_20514158221109411 |
| source | Sage Journals Online |
| title | Effects of body fat components on early renal functions of individuals following kidney donation |
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