The Early Genes c-fos and c-jun: Potential Targets to Modulate Estrogen Action in Endometriosis?

Endometriosis is a common estrogen-dependent disorder. C-fos and c-jun are early transcription factors probably related to estradiol-dependent cell proliferation. C-fos gene expression is higher in endometriotic implants compared to normal endometrium and the distribution of c-Fos protein is higher...

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Bibliographic Details
Published in:Journal of endometriosis 2009-01, Vol.1 (1), p.30-35
Main Authors: Reis, Fernando M., Morsch, Débora M., Rocha, Ana L., Carneiro, Márcia M., Spritzer, Poli M.
Format: Article
Language:English
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Summary:Endometriosis is a common estrogen-dependent disorder. C-fos and c-jun are early transcription factors probably related to estradiol-dependent cell proliferation. C-fos gene expression is higher in endometriotic implants compared to normal endometrium and the distribution of c-Fos protein is higher in the stroma of endometriotic tissue. C-Jun expression is also more abundant in ectopic endometrial tissue. These findings point to an increased estrogen signaling in endometriosis and suggest that c-fos and c-jun could be potential targets to emerging treatments designed to affect selectively the endometriotic tissue, such as tissue-specific gene therapy.
ISSN:2035-9969
2036-282X
DOI:10.1177/228402650900100105