Loading…
Effects of NSAIDs and hydroxyapatite coating on osseointegration: Biomechanical and histological study on rabbits
Purpose: The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on osseointegration. Methods: Hips of 40 New Zealand white rabbits were operated bilaterally. Hydroxyapatite (HA)-coated titanium ro...
Saved in:
Published in: | Journal of orthopaedic surgery (Hong Kong) 2017-01, Vol.25 (1) |
---|---|
Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites |
Online Access: | Request full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Purpose:
The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on osseointegration.
Methods:
Hips of 40 New Zealand white rabbits were operated bilaterally. Hydroxyapatite (HA)-coated titanium rods were implanted into the right femur, and grit-blasted titanium rods were implanted into the left femur. They were divided into three groups. At the end of 8 weeks, both femora of the rabbits were removed and investigated biomechanically and histologically.
Results:
HA-coated implants had a significantly better failure load and “percentage of bone–implant contact” than grit-blasted implants. There was no significant difference between the medication groups as a result of the biomechanical and histologic investigations.
Conclusions:
Our results indicate that NSAIDs did not have any negative effect on the osseointegration. HA-coated implants may provide more tensile strength and greater bone–implant contact rate in comparison with grit-blasted implants. |
---|---|
ISSN: | 1022-5536 2309-4990 |
DOI: | 10.1177/2309499016684410 |