Oxidative stress as a cofactor in spinocerebellar ataxia type 2

Spinocerebellar ataxia type 2 (SCA2) is a redox-sensitive neurodegenerative disease affecting the cerebellum, fibre connections in the cerebellum, the peripheral nervous system, and extracerebellar central pathways. Currently, Cuba has the highest reported global rate for this disease. The aim of th...

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Bibliographic Details
Published in:Redox report : communications in free radical research 2012-03, Vol.17 (2), p.84-89
Main Authors: Guevara-García, Mariela, Gil-del Valle, Lizette, Velásquez-Pérez, Luis, García-Rodríguez, Julio César
Format: Article
Language:English
Subjects:
Adult
Ataxine 2
Ataxins
Cuba - epidemiology
Humans
Nerve Tissue Proteins - metabolism
Neurodegenerative
Oxidative Stress
Redox markers
Review
Spinocerebellar ataxia
Spinocerebellar Ataxias - epidemiology
Spinocerebellar Ataxias - genetics
Spinocerebellar Ataxias - metabolism
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Summary:Spinocerebellar ataxia type 2 (SCA2) is a redox-sensitive neurodegenerative disease affecting the cerebellum, fibre connections in the cerebellum, the peripheral nervous system, and extracerebellar central pathways. Currently, Cuba has the highest reported global rate for this disease. The aim of this review article is to summarize and discuss the current knowledge about evidence of oxidative stress during SCA2. Recent reports have suggested that ataxin 2 and other related factors contribute to the redox imbalance in this disease. It is important to recognize and clarify the molecular mechanisms associated with the redox imbalance to consider ataxias innovative approaches to counteract oxidative stress-induced tissue damage, through alternative therapeutic or nutritional intervention in SCA2 and related diseases.
ISSN:1351-0002
1743-2928
DOI:10.1179/1351000212Y.0000000005