Prenatal protein malnutrition alters the proportion but not numbers of parvalbumin-immunoreactive interneurons in the hippocampus of the adult Sprague-Dawley rat

Prenatal protein malnutrition alters the structure and function of the adult rat hippocampal formation. The current study examines the effect of prenatal protein malnutrition on numbers of parvalbumin-immunoreactive (PV-IR) GABAergic interneurons, which are important for perisomatic inhibition of hi...

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Published in:Nutritional neuroscience 2011-07, Vol.14 (4), p.165-178
Main Authors: Lister, James P, Blatt, Gene J, Kemper, Thomas L, Tonkiss, John, DeBassio, William A, Galler, Janina R, Rosene, Douglas L
Format: Article
Language:English
Subjects:
Animals
CA1 subfield
CA3 subfield
Dentate Gyrus - cytology
Dentate Gyrus - drug effects
Dentate Gyrus - pathology
Female
Hemispheric asymmetry
Inhibition
Interneurons - metabolism
Male
Neurons - cytology
Neurons - pathology
Parvalbumins - metabolism
Pregnancy
Prenatal Exposure Delayed Effects - metabolism
Protein-Energy Malnutrition - metabolism
Rats
Rats, Sprague-Dawley
Stereology
Undernutrition
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Summary:Prenatal protein malnutrition alters the structure and function of the adult rat hippocampal formation. The current study examines the effect of prenatal protein malnutrition on numbers of parvalbumin-immunoreactive (PV-IR) GABAergic interneurons, which are important for perisomatic inhibition of hippocampal pyramidal neurons. Brain sections from prenatally protein malnourished and normally nourished rats were stained for parvalbumin and PV-IR neurons were quantified using stereology in the dentate gyrus, CA3/2 and CA1 subfields, and the subiculum for both cerebral hemispheres. Results demonstrated that prenatal malnutrition did not affect the number of PV-IR interneurons in the hippocampus. Since prenatal protein malnutrition reduces total neuron numbers in the CA1 subfield (1), this results in an altered ratio of PV-IR interneurons to total neuronal numbers (from 1:22.9 in controls to 1:20.5 in malnourished rats). Additionally, there was no hemispheric asymmetry of either PV-IR neuron numbers or ratio of PV-IR:total neuron numbers.
ISSN:1028-415X
1476-8305
DOI:10.1179/147683011X13009738172396