Stem and progenitor cell therapies: recent progress for spinal cord injury repair

Mechanical trauma to the spinal cord is often accompanied by irreversible tissue damage, limited endogenous repair and permanent loss of motor, sensory and autonomic function. The implantation of exogenous cells or the stimulation of endogenous cells, to repopulate and replace or to provide a conduc...

Full description

Saved in:
Bibliographic Details
Published in:Neurological research (New York) 2008-02, Vol.30 (1), p.5-16
Main Authors: Louro, J., Pearse, D. D.
Format: Article
Language:English
Subjects:
Animals
CELL IMPLANTATION
Humans
REPAIR
Spinal Cord Injuries - therapy
SPINAL CORD INJURY
STEM AND PROGENITOR CELLS
Stem Cell Transplantation - methods
Stem Cells - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mechanical trauma to the spinal cord is often accompanied by irreversible tissue damage, limited endogenous repair and permanent loss of motor, sensory and autonomic function. The implantation of exogenous cells or the stimulation of endogenous cells, to repopulate and replace or to provide a conducive environment for repair, offers a promising therapeutic direction for overcoming the multitude of obstacles facing successful recovery from spinal cord injury. Although relatively new to the scene of cell based therapies for reparative medicine, stem cells and their progenitors have been labeled as the 'cell of the future' for revolutionizing the treatment of CNS injury and neurodegenerative disorders. The following review examines the different types of stem cells and their progenitors, their utility in experimental models of spinal cord injury and explores the outstanding issues that still need to be addressed before they move towards clinical implementation.
ISSN:0161-6412
1743-1328
DOI:10.1179/174313208X284070