Retrospective analysis of parenteral magnesium sulfate administration in decreased incidence of clinical and neuroradiological cerebral vasospasm: a single center experience

Objective: Experimental work suggests a neuroprotective role for magnesium sulfate in aneurysmal subarachnoid hemorrhage. We retrospectively review the incidence of clinically relevant vasospasm in patients treated or not with continuous magnesium infusion after onset of subarachnoid hemorrhage. Met...

Full description

Saved in:
Bibliographic Details
Published in:Neurological research (New York) 2009-07, Vol.31 (6), p.621-625
Main Authors: Friedlich, Daniel, Agner, Celso, Boulos, Alan S., Mesfin, Fasil, Feustel, Paul, Bernardini, Gary L., Popp, A. John
Format: Article
Language:English
Subjects:
Adult
Aged
CEREBRAL ANEURYSM
CEREBRAL VASOSPASM
Female
Humans
Infusions, Parenteral
Magnesium - blood
MAGNESIUM SULFATE
Magnesium Sulfate - therapeutic use
Male
Middle Aged
Retrospective Studies
SUBARACHNOID HEMORRHAGE
Subarachnoid Hemorrhage - complications
Subarachnoid Hemorrhage - drug therapy
Vasospasm, Intracranial - complications
Vasospasm, Intracranial - diagnosis
Vasospasm, Intracranial - prevention & control
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: Experimental work suggests a neuroprotective role for magnesium sulfate in aneurysmal subarachnoid hemorrhage. We retrospectively review the incidence of clinically relevant vasospasm in patients treated or not with continuous magnesium infusion after onset of subarachnoid hemorrhage. Methods: All patient records in Albany Medical Center with the diagnosis of SAH between January 1999 and June 2004 were reviewed. Patients who presented to the emergency department within 72 hours of onset were entered in the study. Patients were defined as in clinical vasospasm if there was an acute neurological change in association with abnormal trancranial Doppler (TCD), CT angiogram (CTA) or digital subtraction angiography (DSA). Results: A total of 85 patients were selected. Magnesium sulfate was infused in 43 patients. When compared with patients who did not receive MgSO 4 , there was a statistically significant lower incidence of clinical and radiological vasospasm in those who had the continuous infusion of magnesium sulfate (p
ISSN:0161-6412
1743-1328
DOI:10.1179/174313209X38232