The association of opioid use with incident lower extremity fractures in spinal cord injury

Objective To determine the association between opioid use and lower extremity fracture risk in men with spinal cord injury (SCI). Design Retrospective cohort study. Setting Veterans Affairs Healthcare System. Participants In total, 7447 male Veterans with a history of a traumatic SCI identified from...

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Bibliographic Details
Published in:The journal of spinal cord medicine 2013-03, Vol.36 (2), p.91-96
Main Authors: Carbone, Laura D., Chin, Amy S., Lee, Todd A., Burns, Stephen P., Svircev, Jelena N., Hoenig, Helen M., Akhigbe, Titilola, Weaver, Frances M.
Format: Article
Language:English
Subjects:
Analgesics, Opioid - therapeutic use
Bone mineral density
Cohort Studies
Fractures
Fractures, Bone - epidemiology
Humans
Lower Extremity
Male
Opioids
Osteoporosis
Pain - drug therapy
Pain - etiology
Rehabilitation
Retrospective Studies
Spinal cord injuries
Spinal Cord Injuries - complications
Veterans
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Summary:Objective To determine the association between opioid use and lower extremity fracture risk in men with spinal cord injury (SCI). Design Retrospective cohort study. Setting Veterans Affairs Healthcare System. Participants In total, 7447 male Veterans with a history of a traumatic SCI identified from the Veterans Affairs (VA) Spinal Cord Dysfunction Registry (SCD) from September 2002 through October 2007 and followed through October 2010. Outcome measures Incident lower extremity fractures by use of opioids. Results In individuals identified from the VA SCD Registry 2002-2007, opioid use was quite common, with approximately 70% of the cohort having received a prescription for an opioid. Overall, there were 892 incident lower extremity fractures over the time period of this study (597 fractures in the opioid users and 295 fractures in the non-opioid users). After adjusting for covariates, there was a statistically significant relationship between opioid use and increased risk for lower extremity fractures (hazard ratio 1.82 (95% confidence interval 1.59-2.09)). Shorter duration of use (
ISSN:1079-0268
2045-7723
DOI:10.1179/2045772312Y.0000000060