Short-Term Bactericidal Activity of Amoxicillin and Cefotaxime Against Penicillin-Susceptible and -Resistant Pneumococcal Strains: an In Vitro Pharmacodynamic Simulation

The 8-hour In Vitro activity of serum-simulated concentrations of amoxicillin (obtained after 875 mg oral dose) and cefotaxime (obtained after a 1 g i.v. dose), against 20 strains of the 5 Streptococcus pneumoniae serotypes most prevalent in Spain, was explored. Despite a greater initial inocula dec...

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Bibliographic Details
Published in:Journal of chemotherapy (Florence) 2000-04, Vol.12 (2), p.124-128
Main Authors: Fenoll, A., Casal, J., Gimenez, M.J., Jado, I., Aguilar, L.
Format: Article
Language:English
Subjects:
Administration, Oral
Amoxicillin - administration & dosage
Amoxicillin - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Cefotaxime - administration & dosage
Cefotaxime - pharmacology
Cephalosporins - administration & dosage
Cephalosporins - pharmacology
Humans
Infusions, Intravenous
Medical sciences
Microbial Sensitivity Tests - methods
Penicillin Resistance
Penicillins - administration & dosage
Penicillins - pharmacology
Pharmacology. Drug treatments
Pneumococcal Infections - epidemiology
Pneumococcal Infections - microbiology
Spain - epidemiology
Streptococcus pneumoniae - classification
Streptococcus pneumoniae - drug effects
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Summary:The 8-hour In Vitro activity of serum-simulated concentrations of amoxicillin (obtained after 875 mg oral dose) and cefotaxime (obtained after a 1 g i.v. dose), against 20 strains of the 5 Streptococcus pneumoniae serotypes most prevalent in Spain, was explored. Despite a greater initial inocula decrease observed with cefotaxime against the resistant strains at the first sampling time, a decrease ≥99.9% was obtained with both β-lactams from 6h onwards against the penicillin-susceptible strains; the same was observed for the penicillin-resistant strains with amoxicillin but not with cefotaxime.
ISSN:1120-009X
1973-9478
DOI:10.1179/joc.2000.12.2.124