In Vitro Antifungal Activity of Sertaconazole Against 309 Dermatophyte Clinical Isolates

• Published in: Journal of chemotherapy (Florence) 2003-12, Vol.15 (6), p.555-557
• Main Authors: Carrillo-Muñoz, A.J., Fernandez-Torres, B., Guarro, J.
• Format: Article
• Language: English
• Subjects: Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - pharmacology; Arthrodermataceae - classification; Arthrodermataceae - drug effects; Biological and medical sciences; Dermatomycoses - drug therapy; Dermatomycoses - microbiology; Drug Resistance, Fungal; Female; Fungi - drug effects; Fungi - isolation & purification; Humans; Imidazoles - pharmacology; Male; Medical sciences; Microbial Sensitivity Tests; Pharmacology. Drug treatments; Sensitivity and Specificity; Thiophenes - pharmacology
• ISSN: 1120-009X; 1973-9478
• DOI: 10.1179/joc.2003.15.6.555

Three hundred and nine strains belonging to 11 species of dermatophyte moulds were tested against sertaconazole following mainly the National Committee for Clinical Laboratory Standards (M38-P) for filamentous fungi. However, several important factors such as the temperature (28°C vs 35°C) and time of incubation (4-10 d vs 21-74 h), have been modified. Sertaconazole was active against all the clinically important dermatophyte moulds involved in human infections tested. Overall geometric mean MIC of sertaconazole was 0.21 μg/ml with a MIC range of 0.01-8 μg/ml. MIC 50 and MIC 90 were respectively of 0.25 and 1 μg/ml. Sertaconazole was very active against Epidermophyton floccosum, Trichophyton rubrum, Trichophyton tonsurans and Microsporum canis (geometric means 0.08, 0.13, 0.13 and 0.19 μg/ml respectively). Microsporum audouinii had the lowest susceptibility in the study (geometric mean 0.59 μg/ml). Considering MIC 50 and MIC 90 these differences were significantly in favor of the activity of sertaconazole against E. floccosum (0.06 and 0.5 μg/ml respectively).