Evaluation of Acute and Early Cardiotoxicity in Survivors of Hodgkin's Disease Treated with ABVD or BEACOPP Regimens

The study was conducted to compare the presence of cardiotoxicity after the treatment of Hodgkin's disease with the standard ABVD or BEACOPP protocol. We examined 29 patients treated by means of the ABVD regimen and 34 treated with the BEACOPP regimen. Using rest echocardiography we assessed th...

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Bibliographic Details
Published in:Journal of chemotherapy (Florence) 2006-04, Vol.18 (2), p.199-208
Main Authors: Elbl, L., Vasova, I., Kral, Z., Tomaskova, I., Smardova, L., Wagnerova, B., Jedlicka, F., Vorlicek, J.
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Bleomycin - adverse effects
Bleomycin - therapeutic use
cardiotoxicity
Cyclophosphamide - adverse effects
Cyclophosphamide - therapeutic use
Dacarbazine - adverse effects
Dacarbazine - therapeutic use
doxorubicin
Doxorubicin - adverse effects
Doxorubicin - therapeutic use
Echocardiography
Etoposide - adverse effects
Etoposide - therapeutic use
Female
Follow-Up Studies
Heart Diseases - chemically induced
Heart Diseases - diagnostic imaging
Hematologic and hematopoietic diseases
Hodgkin Disease - drug therapy
Hodgkin's disease
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Pharmacology. Drug treatments
Prednisone - adverse effects
Prednisone - therapeutic use
Procarbazine - adverse effects
Procarbazine - therapeutic use
Prospective Studies
Survivors
Ventricular Function, Left
Vinblastine - adverse effects
Vinblastine - therapeutic use
Vincristine - adverse effects
Vincristine - therapeutic use
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Summary:The study was conducted to compare the presence of cardiotoxicity after the treatment of Hodgkin's disease with the standard ABVD or BEACOPP protocol. We examined 29 patients treated by means of the ABVD regimen and 34 treated with the BEACOPP regimen. Using rest echocardiography we assessed the left ventricular function before and after the therapy. One year after the completion of therapy, a control examination was performed with a battery of tests; the rest and dynamic stress echocardiography and cardiopulmonary tests were carried out to assess cardiopulmonary performance. A similar significant deterioration of ejection fraction and diastolic function was apparent after the treatment in both sub-groups with a further progression at the one-year control. Only one patient from the BEACOPP sub-group showed a pathological drop of EF
ISSN:1120-009X
1973-9478
DOI:10.1179/joc.2006.18.2.199