Mast cells produce interleukin-25 upon FcεRI-mediated activation

Interleukin-25 (IL-25) is a recently described T helper 2 (TH2) cell–derived cytokine that belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non–T-cell population. Here, we show that mast cells are also potent IL-25–producing cells. When bone marrow...

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Bibliographic Details
Published in:Blood 2003-05, Vol.101 (9), p.3594-3596
Main Authors: Ikeda, Kei, Nakajima, Hiroshi, Suzuki, Kotaro, Kagami, Shin-ichiro, Hirose, Koichi, Suto, Akira, Saito, Yasushi, Iwamoto, Itsuo
Format: Article
Language:English
Subjects:
Animals
Calcimycin - pharmacology
Calcineurin - physiology
Gene Expression Regulation - drug effects
Immunoglobulin E - pharmacology
Interleukin-17 - biosynthesis
Interleukin-17 - genetics
Interleukins - biosynthesis
Interleukins - genetics
Mast Cells - drug effects
Mast Cells - metabolism
Mice
Receptors, IgE - physiology
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - biosynthesis
Tetradecanoylphorbol Acetate - pharmacology
Th2 Cells - metabolism
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Summary:Interleukin-25 (IL-25) is a recently described T helper 2 (TH2) cell–derived cytokine that belongs to the IL-17 family and induces the production of IL-4, IL-5, and IL-13 from an unidentified non–T-cell population. Here, we show that mast cells are also potent IL-25–producing cells. When bone marrow–derived mast cells were stimulated by immunoglobulin E cross-linking, IL-25 mRNA was induced within 30 minutes in a calcineurin-dependent manner, and the levels of IL-25 mRNA were comparable with those of activated TH2 cells. Production of IL-25 by mast cells was also detected at protein levels by immunoblotting. These results suggest that mast cells may enhance TH2-type immune response by producing IL-25.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2002-09-2817