The new oral anticoagulants

Although their first application in clinical practice occurred in the 1940s, vitamin K antagonists remain the only form of oral anticoagulant medication approved for long-term use. Although the available vitamin K antagonists are highly effective for the prevention and/or treatment of most thromboti...

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Bibliographic Details
Published in:Blood 2010-01, Vol.115 (1), p.15-20
Main Authors: Garcia, David, Libby, Edward, Crowther, Mark A.
Format: Article
Language:English
Subjects:
Administration, Oral
Anticoagulants - administration & dosage
Anticoagulants - pharmacology
Biological and medical sciences
Clinical Trials as Topic
Drug Discovery
Hematologic and hematopoietic diseases
Humans
Medical sciences
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Summary:Although their first application in clinical practice occurred in the 1940s, vitamin K antagonists remain the only form of oral anticoagulant medication approved for long-term use. Although the available vitamin K antagonists are highly effective for the prevention and/or treatment of most thrombotic disease, the significant interpatient and intrapatient variability in dose-response, the narrow therapeutic index, and the numerous drug and dietary interactions associated with these agents have led clinicians, patients, and investigators to search for alternative agents. Three new orally administered anticoagulants (apixaban, dabigatran, and rivaroxaban) are in the late stages of development and several others are just entering (or moving through) earlier phases of investigation. These novel anticoagulant medications are being studied for the prevention and treatment of venous thromboembolism, the treatment of acute coronary syndromes and the prevention of stroke in patients with atrial fibrillation. This review summarizes published clinical trial data pertinent to apixaban, dabigatran, and rivaroxaban.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2009-09-241851