HLA-a0101 Expression Correlates with Increased Risk of Severe Cutaneous Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Introduction: Acute graft-versus-host disease (aGVHD) remains a substantial cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (alloHSCT). aGVHD most commonly affects the skin, for which there is a high treatment response after both unmodified and ex-vivo CD34+...

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Bibliographic Details
Published in:Blood 2018-11, Vol.132 (Supplement 1), p.4564-4564
Main Authors: Fonseca, Maira, Jakubowski, Ann A., Devlin, Sean M, Young, James W., Fatmi, Samira A, Maloy, Molly, Giralt, Sergio, Ponce, Doris, Markova, Alina
Format: Article
Language:English
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Summary:Introduction: Acute graft-versus-host disease (aGVHD) remains a substantial cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (alloHSCT). aGVHD most commonly affects the skin, for which there is a high treatment response after both unmodified and ex-vivo CD34+ selected/T-cell depleted (TCD) alloHSCT grafts. We identified a cluster of patients, however, who developed severe refractory cutaneous aGVHD and expressed MHC class I HLA-A*0101 allele. Although the effect of HLA polymorphisms on cutaneous aGVHD is unknown, we hypothesized that HLA-A*0101 expression correlates with worse cutaneous aGVHD after alloHSCT. Methods: We evaluated 831 patients who underwent either an unmodified or TCD allograft at a single institution between 03/2010 and 02/2017. We excluded patients who received
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2018-99-110405