The Prognostic Impact of t(14;20) in Multiple Myeloma - a Multicenter Retrospective Study of 26 Patients

Introduction The prognosis in multiple myeloma (MM) is based upon complex biological and clinical features. One of the strongest predictors of outcome are the intrinsic genetic abnormalities in the malignant plasma cells. t(14;20), as other chromosome 14 abnormalities, deregulates the c-musculoapone...

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Published in:Blood 2018-11, Vol.132 (Supplement 1), p.5600-5600
Main Authors: Jurczyszyn, Artur, Goldman-Mazur, Sarah, Castillo, Jorge J., Waszczuk-Gajda, Anna, Grząśko, Norbert, Bittrich, Max, Yee, Andrew J, Suska, Anna, Madduri, Deepu, Chhabra, Saurabh, Kleman, Ariel, Hari, Parameswaran, Goldberg, Stuart L., Chappell, Aimee, Gentile, Massimo, Vesole, David H.
Format: Article
Language:English
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Summary:Introduction The prognosis in multiple myeloma (MM) is based upon complex biological and clinical features. One of the strongest predictors of outcome are the intrinsic genetic abnormalities in the malignant plasma cells. t(14;20), as other chromosome 14 abnormalities, deregulates the c-musculoaponeurotic fibrosarcoma (c-MAF) oncogene. Due to the relative rarity of t(14;20) [
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2018-99-115816