Integrated Genome Wide Association Study (GWAS) Identifies SNPs Associated with Outcome in Pediatric AML

Acute myeloid leukemia (AML) treatment response remains poorly understood. Although multiple studies have focused on understanding the transcriptomic and epigenetic landscape of AML, a genome-wide analysis of SNPs in pediatric AML has not yet been investigated in depth. Thus, we sought to identify g...

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Bibliographic Details
Published in:Blood 2018-11, Vol.132 (Supplement 1), p.2758-2758
Main Authors: Elsayed, Abdelrahman H, Wu, Huiyun, Cao, Xueyuan, Meshinchi, Soheil, Ribeiro, Raul, Rubnitz, Jeffrey, Pounds, Stanley, Lamba, Jatinder K
Format: Article
Language:English
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Summary:Acute myeloid leukemia (AML) treatment response remains poorly understood. Although multiple studies have focused on understanding the transcriptomic and epigenetic landscape of AML, a genome-wide analysis of SNPs in pediatric AML has not yet been investigated in depth. Thus, we sought to identify genetic variants predictive of AML response, relapse, and survival in pediatric AML patients. For this study, we generated genome-wide SNP data patients (n=160) treated on the multicenter AML02 clinical trial (ClinicalTrials.gov Identifier: NCT00136084) using Infinium Omni 2.5M Exome Beadchip. Standard GWAS QC procedure was followed in order to remove SNPs with call rate < 95%, monomorphic SNPs, SNPs with MAF
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2018-99-120367