Prediction of Cardiac Complications in SCD

Introduction: Cardiac magnetic resonance (CMR) is the non-invasive gold standard for the quantification of biventricular functional parameters and for myocardial tissue characterization. The aim of this study was to prospectively assess the predictive value of CMR parameters for cardiovascular compl...

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Published in:Blood 2019-11, Vol.134 (Supplement_1), p.1026-1026
Main Authors: Pepe, Alessia, Pistoia, Laura, Gamberini, Maria Rita, Macchi, Silvia, Commendatore, Francesca Valeria, Facchini, Elena, Pitrolo, Lorella, Celli, Mauro, Maggio, Aurelio, Preziosi, Paolo, Positano, Vincenzo, Meloni, Antonella
Format: Article
Language:English
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Summary:Introduction: Cardiac magnetic resonance (CMR) is the non-invasive gold standard for the quantification of biventricular functional parameters and for myocardial tissue characterization. The aim of this study was to prospectively assess the predictive value of CMR parameters for cardiovascular complications in sickle cell disease (SCD) patients. Methods: We considered 102 white SCD patients (34.38±12.67 years, 53 females) consecutively enrolled in the Myocardial Iron Overload in Thalassemia (MIOT) network. Myocardial iron overload (MIO) was measured by the multislice multiecho T2* technique. Atrial dimensions and biventricular function parameters were quantified by cine images. Results: At baseline CMR only two patients had MIO (global heart T2*
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2019-121843