Profound Lymphopenia at the Time of ATG Administration Is Not Predictive of Survivals after Allotransplant Using Purine Analogue/Busulfan-Based Conditioning Regimen

Introduction: Prophylactic T cell depletion with antithymocyte globulin (ATG) remains a standard of care for GVHD prophylaxis during allotransplant (ASCT). Although the optimal ATG dosing strategy is still unknown, recent studies have reported that recipient absolute lymphocyte counts (ALC) at the t...

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Published in:Blood 2019-11, Vol.134 (Supplement_1), p.1985-1985
Main Authors: Jullien, Maxime, Guillaume, Thierry, Peterlin, Pierre, Garnier, Alice, Le Bourgeois, Amandine, Debord, Camille, Mahe, Beatrice, Dubruille, Viviane, Wuilleme, Soraya, Blin, Nicolas, Touzeau, Cyrille, Gastinne, Thomas, Tessoulin, Benoit, Le Bris, Yannick, Eveillard, Marion, Duquesne, Alix, Moreau, Philippe, Le Gouill, Steven, Bene, Marie-Christine, Chevallier, Patrice
Format: Article
Language:English
Online Access:Get full text
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Summary:Introduction: Prophylactic T cell depletion with antithymocyte globulin (ATG) remains a standard of care for GVHD prophylaxis during allotransplant (ASCT). Although the optimal ATG dosing strategy is still unknown, recent studies have reported that recipient absolute lymphocyte counts (ALC) at the time of ATG administration may predict survivals in ASCT with unrelated donors, suggesting that the dose (especially at the cut off of
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2019-122013