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Multicenter Prospective Evaluation of Diagnostic Potential of Flow Cytometric Aberrancies in Myelodysplastic Syndromes

Background: Myelodysplastic syndromes (MDS) are considered clonal diseases and are diagnosed according to WHO by cytomorphology and cytogenetics. The diagnostic potential of flow cytometric aberrancies has not yet been comprehensively evaluated. Aim: Multicenter prospective evaluation of diagnostic...

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Bibliographic Details
Published in:Blood 2021-11, Vol.138 (Supplement 1), p.3995-3995
Main Authors: Kern, Wolfgang, Westers, Theresia M., Bellos, Frauke, Bene, Marie C, Bettelheim, Peter, Eidenschink Brodersen, Lisa, Burbury, Kate, Chu, Sung-Chao, Cullen, Matthew, Porta, Matteo Della, Dunlop, Alan Stewart, Johansson, Ulrika, Matarraz, Sergio, Oelschlaegel, Uta, Ogata, Kiyoyuki, Porwit, Anna, Preijers, Frank W.M.B., Psarra, Katherina, Saft, Leonie, Subirá, Dolores, Weiss, Elisabeth, Van de Loosdrecht, Arjan A.
Format: Article
Language:English
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Summary:Background: Myelodysplastic syndromes (MDS) are considered clonal diseases and are diagnosed according to WHO by cytomorphology and cytogenetics. The diagnostic potential of flow cytometric aberrancies has not yet been comprehensively evaluated. Aim: Multicenter prospective evaluation of diagnostic potential of flow cytometric aberrancies predefined according to European LeukemiaNet (ELN). Methods: 1682 patients undergoing diagnostics for suspected MDS according to WHO 2016 criteria were analyzed in parallel by flow cytometry according to ELN recommendations. Results: Median age was 72 years (18-97). MDS, MPN-RS-T or CMML were confirmed by cytomophology in 1029 (61%) cases, 653 (39%) were non-MDS. IPSS-R data was available in 857 (51%). An overall flow cytometric readout was available in 1679 (99.8%). 1001 (60%) were in agreement with MDS while 678 (40%) were not. Flow cytometric readout significantly correlated with cytomorphologic diagnosis (p
ISSN:0006-4971
1528-0020
DOI:10.1182/blood-2021-152298