Clinical Features and Effects of Eradication on Helicobacter Pylori Positive 207 ITP Cases in Japan

• Published in: Blood 2004-11, Vol.104 (11), p.2071-2071
• Main Authors: Fujimura, Kingo, Kuwana, Masataka, Kurata, Yoshiyuki, Imamura, Masahiro, Harada, Hiroshi, Sakamaki, Hisashi, Teramura, Masanao, Koda, Kyuhei, Nomura, Shosaku, Sugihara, Sayaka, Shimomura, Takeshi, Fujimoto, Tetsuro Takahiro, Oyashiki, Kazuma, Ikeda, Yasuo
• Format: Article
• Language: English
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V104.11.2071.2071

In 1998, Gasbarrini et al reported that in ITP cases with Helicobacter pylori (H.pylori) infection, elevation of platelet counts was observed by eradication of this bacterium. Since then, several reports from Italy and Japan confirmed the elevation of platelet counts after eradication. However, the characteristic background in the H.pylori positive ITP and eradication effects on platelet counts is unclear. On the other hand, reports from Spain, North Europe and USA could not show the evidence that eradication is effective on elevating platelet counts in H.pylori positive ITP. Therefore, we designed a nationwide retrospective study in Japan to evaluate the incidence of H.pylori positive ITP cases and the effects of eradication on platelet counts and to clear above problems. Four hundred and thirty-five ITP cases were enrolled over a period of one and half years (2002. 7~2003.12) from 12 hospitals. H. pylori infection was found in 300 cases(65%), who were significantly (P