Minimal Residual Disease Monitoring after Reduced Intensity Conditioning (RIC) Allogeneic Transplantation: May Help To Individualize Post-Transplant Immunotherapeutic Strategies

We have analyzed the impact of MRD monitoring (detected by flow cytometry) on the outcome of 56 patients undergoing RIC allogeneic SCT. Of them, 67% reached complete remission (CR), 11% partially responded (PR) and 22% progressed or did not respond. MRD assessment after transplant distinguished diff...

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Bibliographic Details
Published in:Blood 2005-11, Vol.106 (11), p.5397-5397
Main Authors: Diez-Campelo, Maria, Perez-Simon, Jose A., Perez, Jose J., Caballero, Dolores M., Vidriales, Belen, Alcoceba, Miguel, Vazquez, Lourdes, Gonzalez, Marcos, Canizo, Consuelo M., Lopez-Berges, Consuelo M., Lopez-Fidalgo D, Jesus, Miguel, J.F. San
Format: Article
Language:English
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Summary:We have analyzed the impact of MRD monitoring (detected by flow cytometry) on the outcome of 56 patients undergoing RIC allogeneic SCT. Of them, 67% reached complete remission (CR), 11% partially responded (PR) and 22% progressed or did not respond. MRD assessment after transplant distinguished different risk populations. At day +100, 80% of patients with high MRD levels (>10−2 leukemia asocciatted immunophenotypical cells, LAIP cells) versus 27% of patients with low MRD (
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V106.11.5397.5397