IgA and IgG Hypogammaglobulinemia Are Associated with Mutations in the APRIL/BLYS Receptor TACI in Waldenstrom's Macroglobulinemia (WM)

IgA and IgG hypogammaglobulinemia are a common finding in patients with WM which may contribute to recurrent infections seen in up to half of WM patients. The etiology for this finding remains unclear. As part of these studies, we investigated the prevalence and genetic basis for IgA and IgG hypogam...

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Published in:Blood 2006-11, Vol.108 (11), p.228-228
Main Authors: Hunter, Zachary, Leleu, Xavier, Hatjiharissi, Evdoxia, Santos, Daniel, Xu, Lian, Ho, Alan, Bakthavachalam, Vinod, Moreau, Anne-Sophie, O'Connor, Kelly, Soumerai, Jacob, Patterson, Christopher, Ghobrial, Irene, Hamilton, Susanna, Verselis, Sigitas, Fox, Edward, Treon, Steven
Format: Article
Language:English
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Summary:IgA and IgG hypogammaglobulinemia are a common finding in patients with WM which may contribute to recurrent infections seen in up to half of WM patients. The etiology for this finding remains unclear. As part of these studies, we investigated the prevalence and genetic basis for IgA and IgG hypogammaglobulinemia among 89 previously untreated patients with the clinicopathological diagnosis of WM. Their median IgM was 2,980 (180–12,400) mg/dl, median BM involvement was 35% (5%–95%) and median B2M was 2.7 (1.4–13.7 mg/dL). Fifty-six (63%) and 66 (74%) of these patients demonstrated IgG (
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V108.11.228.228