Clinical Significance of Free Circulating CD34 in Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome

CD34 is an approximately 116-kd glycophosphoprotein expressed in hematopoietic progenitor cells, endothelial cells, and some mesenchymal and neural cells. CD34 is a typical adhesion molecule capable of inducing the cell signal transduction pathway leading to adhesion and differentiation. We used a n...

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Bibliographic Details
Published in:Blood 2006-11, Vol.108 (11), p.4495-4495
Main Authors: Hodge, Menna, Giles, Francis, Abdool, Adam, O'Brien, Susan, Keating, Michael, Jilani, Iman, Estrov, Zeev, Estey, Elihu, Kantarjian, Hagop, Albitar, Maher
Format: Article
Language:English
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Summary:CD34 is an approximately 116-kd glycophosphoprotein expressed in hematopoietic progenitor cells, endothelial cells, and some mesenchymal and neural cells. CD34 is a typical adhesion molecule capable of inducing the cell signal transduction pathway leading to adhesion and differentiation. We used a newly developed bead-based assay to measure cell-free circulating CD34 (cCD34) in the plasma of patients with acute myeloid leukemia (AML; n = 98) and myelodysplastic syndrome (MDS; n = 50). Levels of cCD34 were significantly higher in AML (median 10983, range: 844–100,4191 U/10 μl than in MDS (median: 8749, range:102–791,350 U/10 μl) patients (P
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V108.11.4495.4495