Correlation of New Method for Measuring Plasma Myeloperoxidase with Clinical Behavior in Acute Myeloid Leukemia and Myelodysplastic Syndrome

We previously reported that levels of myeloperoxidase (MPO) enzyme in plasma of patients with acute myeloid leukemia (AML) may correlate with aggressive disease. However, we found poor reproducibility and significant variability from lot to lot when commercially available kits are used. We developed...

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Bibliographic Details
Published in:Blood 2007-11, Vol.110 (11), p.4321-4321
Main Authors: Abdool, Adam, Wang, Xiugiang, Jilani, Iman, Zhou, Weidong, Kantargian, Hagop, Estey, Elihu, Giles, Francis, Albitar, Maher
Format: Article
Language:English
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Summary:We previously reported that levels of myeloperoxidase (MPO) enzyme in plasma of patients with acute myeloid leukemia (AML) may correlate with aggressive disease. However, we found poor reproducibility and significant variability from lot to lot when commercially available kits are used. We developed a cytometric beads assay (CBA) for measuring plasma MPO that shows high reproducibility (CV70 ng/ml) had shorter survival (P=0.05). Despite there was a correlation between the commercially available kit for measuring MPO and our CBA method (r=0.71, P
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V110.11.4321.4321