The Impact of Relative Dose Intensity (RDI) of CHOP on Outcome of Diffuse Large B-Cell Lymphoma: Results of a Single Center Study

Introduction: The achievement of a clinical response to the first induction chemotherapy has been considered for predicting survival in patients (pts) with aggressive non-Hodgkin lymphoma (NHL). Reduced dose intensity of chemotherapy has been likely to compromise long-term outcome of the patients wi...

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Published in:Blood 2007-11, Vol.110 (11), p.4456-4456
Main Authors: Terada, Yoshiki, Nakamae, Hirohisa, Nakane, Takahiko, Koh, Hideo, Takeoka, Yasunobu, Moriguchi, Ran, Aimoto, Mizuki, Akazawa, Yuki, Wada, Eri, Kanashima, Hiroshi, Sakamoto, Erina, Koh, Ki-Ryang, Yamane, Takahisa, Ohta, Kensuke, Nakao, Yoshitaka, Teshima, Hirofumi, Hino, Masayuki
Format: Article
Language:English
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Summary:Introduction: The achievement of a clinical response to the first induction chemotherapy has been considered for predicting survival in patients (pts) with aggressive non-Hodgkin lymphoma (NHL). Reduced dose intensity of chemotherapy has been likely to compromise long-term outcome of the patients with aggressive NHL treated with a standard chemotherapy of cyclophosphamide (CY), doxorubicin (ADR), vincristine and prednisone (CHOP). In particular, recent studies have revealed the relevance of relative dose intensity (RDI) to clinical outcomes, with reduced RDI leading to a poor survival, as well as the impact of RDI
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V110.11.4456.4456