AV513 Promotes Tissue Factor-Mediated Coagulation in Fresh Human Whole Blood from Severe and Moderate Hemophilia a Subjects

The sulfated polysaccharide extract AV513 accelerates effective clotting of plasma from severe hemophilia A and B subjects, primarily through the extrinsic pathway by inhibiting TFPI activity. AV513 is efficacious in normalizing bleeding times in hemophilia A dogs when administered orally or subcuta...

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Bibliographic Details
Published in:Blood 2008-11, Vol.112 (11), p.1223-1223
Main Authors: Powell, Jerry Sherman, Knappe, Sabine, Harrison, Janet A, Patarroyo-White, Susannah, Johnson, Kirk, Prasad, Srinivasa
Format: Article
Language:English
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Summary:The sulfated polysaccharide extract AV513 accelerates effective clotting of plasma from severe hemophilia A and B subjects, primarily through the extrinsic pathway by inhibiting TFPI activity. AV513 is efficacious in normalizing bleeding times in hemophilia A dogs when administered orally or subcutaneously, either alone or in the presence of very low levels of factor VIII. In this report, we have examined the effects on hemostasis of different concentrations of AV513 (0.25 to 5 ug/mL) added to fresh whole blood from eight severe (FVIII
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V112.11.1223.1223