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NDRG1 Expression Is Inhibited in AML and Its Knockdown Attenuates Neutrophil Differentiation

The N-myc down-regulated gene 1 (NDRG1) is a stressed induced protein whose expression is associated with growth arrest and differentiation of tumor cells. Although the exact function of NDRG1 protein remains unknown, various studies support its role as a suppressor of tumor metastasis. In prostate,...

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Bibliographic Details
Published in:Blood 2008-11, Vol.112 (11), p.927-927
Main Authors: Tschan, Mario P., Shan, Deborah, Laedrach, Judith, Eyholzer, Marianne, Leibundgut, Elisabeth Oppliger, Baerlocher, Gabriela, Tobler, Andreas, Stroka, Deborah, Fey, Martin F.
Format: Article
Language:English
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Summary:The N-myc down-regulated gene 1 (NDRG1) is a stressed induced protein whose expression is associated with growth arrest and differentiation of tumor cells. Although the exact function of NDRG1 protein remains unknown, various studies support its role as a suppressor of tumor metastasis. In prostate, colon and breast cancer its expression is associated with a better disease prognosis and patient survival. In hematopoietic cells, NDRG1 was identified in a differential display screen for differentiation-related genes in human myelomonocytic U937 cells. In the present study, we sought to investigate the role of NDRG1 in myeloid differentiation. To this end we first evaluated NDRG1 mRNA expression in acute myeloid leukemia (AML; n=82) patient samples as well as in CD34+ progenitor cells (n=5) and neutrophils (n=6) of healthy donors using quantitative real-time RT-PCR. We found significantly higher NDRG1 mRNA levels in granulocytes as compared to CD34+ (p=0.0043) or AML blast cells (p
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V112.11.927.927