Difference of Allo-Immunity to Erythrocytes in Asian Countries: Cooperative Study of Allo-Immunity to Antigen Diversity in Asian Population

• Published in: Blood 2009-11, Vol.114 (22), p.2112-2112
• Main Authors: Watanabe, Hiroko, Takeshita, Akihiro, Kim, Dae Won, Kwon, So Yong, Han, Kyou Sup, Suh, Jang Soo, Natalie, Chan Pui Ha, Nadarajan, Veera Sekaran, Permpikul, Parichart, Marican, Nuranissa Bte Yacob, Uchikawa, Makoto, Kino, Shuichi, Ohto, Hitoshi
• Format: Article
• Language: English
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V114.22.2112.2112

Abstract 2112 Poster Board II-89 (Purpose) Asian populations have a wide variety of genetics and circumstances. Therefore, immune responses to allo-antigens may differ from those that are common among American and European populations. However, we have little information from Asian populations, and collaborative international study is required to improve the success of blood transfusions and transplantations. Therefore, we tried to analyze allo-antibodies (Abs) to erythrocyte antigens in patients from Asian countries. (Method) Forty-eight institutes, including those in Japan (29), Korea (15), Hong Kong (1), Singapore (1), Malaysia (1) and Thailand (1), participated to this cooperative study of allo-antibodies to erythrocyte antigens in Asian populations. We investigated the number of blood grouping tests, cross matching tests, and erythrocyte irregular Ab analyses as well as information of institutes including total number of bed, operations and transfusions performed. We also investigated methods adopted for screening and detecting irregular Abs to erythrocyte antigens. Furthermore, we studied the frequencies of irregular Abs to erythrocytes (D, C ,c, E, e, f, Ce, P1, M, N, S, s, Mia, Lea, Leb, Jka, Jkb, Jk3, Fya, Fyb,K, k, Kpa, Kpb, Jsa, Jsb, Dia, Dib, Lua, Lub, Xga and H), and compared them among Asian countries. The total number of independent cases included more than 866,000 patients. If a case was analyzed multiple times, we counted it as one case. Multiple antibodies detected in a patient were separately summarized. (Results) Ab screening methods adopted in these institutes included gel columns, beads columns, traditional tubes or some combination of these three. There was no difference in the methods including the erythrocyte panel adopted. Among the serum of 8,880 patients (male /female: 1 /1.55) 10,069 antibodies were detected. The numbers of these patients registered in each country are as follows; 4,222 in Japan, 2,423 in Korea, 975 in Malaysia, 622 in Thailand, 612 in Hong Kong and 26 in Singapore. On average, anti-E Ab was detected in 25.7% (min-max country, 14.3-32.2%) of patients, anti-Lea 20.9 % (3.2-30.4), anti-Mia 7.3% (0-49.4), anti-P1 6.6 % (0-10.6), anti-M 5.6 % (0-7.0), ant-c+E 4.9 % (1.6-8.5), anti-Leb 4.3 % (0-7.6), anti-D 4.0 % (0-16.2), anti-Fyb 2.2 % (0-3.7), anti-Dia 1.9 % (0-3.3), anti-Jka 1.7 % (0.8-7.7), anti-C+e 1.5 % (0-3.3), anti-Lea+Leb 1.4 % (0-5.8), anti-S 1.1 % (0-1.9), anti-c 1.1 % (0-2.3) and other Abs 9.9 %. Anti-D