Association Between Genetic Polymorphism in DNA Repair Genes and Acute Myeloid Leukemia

• Published in: Blood 2009-11, Vol.114 (22), p.4131-4131
• Main Authors: Kim, Hee Nam, Kim, Nan young, Yu, Li, Tran, Huong Thi Thanh, Kim, Yeo-Kyeoung, Lee, Il-Kwon, Yang, Deok-Hwan, Lee, Je-Jung, Kim, Hee-Je, Min, Woo-Sung, Park, Moo-Rim, Jo, Deog Yeon, Won, Jong Ho, Kwak, Jae-Yong, Kim, Hyeoung-Joon
• Format: Article
• Language: English
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V114.22.4131.4131

Abstract 4131 Genetic variants in DNA repair genes may affect DNA repair capacity and modulate cancer susceptibility. We analyzed genetic polymorphisms of 11 DNA repair genes: XRCC4, BRCA1, WRN, RAD51, XRCC3, ERCC1, ERCC2, XPC, OGG1, XRCC1 and MGMT to evaluate the association and risk of acute myeloid leukemia (AML). A large-scale population-based, case-control study of 1700 controls and 659 cases was conducted in Chonnam National University Hwasun Hospital, Korea. Three single-nucleotide polymorphisms(SNPs), ERCC1 IVS5 +33 CC, WRN 787 GG and XRCC1 399 GA genotypes were associated with decreased risk for AML [odds ratio (OR) = 0.71; 95% confidence interval (CI) = 0.54-0.92, p=0.01 for IVS5 +33 CC, 0.67; 0.50–0.89, p=0.006 for 3149 GG and 0.81; 0.67–0.98, p=0.031 for 1316 GA]. We found no differences in the XRCC4 S307, BRCA1 P87L, RAD51 –G135C, XRCC3 T241M, ERCC2 K751Q, XPC K939Q, OGG1 S326C and MGMT L84F genotypes. Our results suggest that these 3 SNPs in DNA repair genes may affect AML susceptibility by modulating activities to maintain the genome integrity of each individual. No relevant conflicts of interest to declare.