Severe Rhabdomyolysis and Acute Renal Failure Secondary to Use of All–Trans-Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

Abstract 4138 To report a case of All–Trans-Retinoic Acid(ATRA)-induced rhabdomyolysis and acute renal failure in a patient with Acute Promyelocytic Leukemia(APL). A 44-year-old man with underlying APL. Results of the laboratory investigation were as follows: WBC 1.400/dl, hemoglobin 5.7 g/dl and pl...

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Bibliographic Details
Published in:Blood 2009-11, Vol.114 (22), p.4138-4138
Main Authors: Qian, Shenxian, Xie, Yaping, Huang, Xilian, Gao, DaQuan, Liu, LiRong, Chen, Kuang
Format: Article
Language:English
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Summary:Abstract 4138 To report a case of All–Trans-Retinoic Acid(ATRA)-induced rhabdomyolysis and acute renal failure in a patient with Acute Promyelocytic Leukemia(APL). A 44-year-old man with underlying APL. Results of the laboratory investigation were as follows: WBC 1.400/dl, hemoglobin 5.7 g/dl and platelets 15000/dl; prothrombin time 15.8 sec, activated partial thromboplastin time 23.4 sec, fibrinogen 75mg/dL (200-590 mg/dL), 3P(+), D-dimer>0.8 mg/dl(0.8 mg/dl(
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V114.22.4138.4138