Prognostic Impact of Monosomal Karyotype in Patients with Myelodysplastic Syndrome and Abnormal Karyotype. A Report From the Spanish Group of MDS (GESMD)

Abstract 1724 Cytogenetic abnormalities (CA) are the most important prognostic factor in patients with myelodysplastic syndromes (MDS). Monosomal karyotype (MK) defined as the presence of at least two autosomal monosomies or one monosomy plus other structural CA, has been associated with poor progno...

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Published in:Blood 2011-11, Vol.118 (21), p.1724-1724
Main Authors: Valcárcel, David, Adema, Vera, Mallo, Mar, Ortega, Margarita, Nomdedeu, Benet, Sanz, Guillermo, Luño, Elisa, Consuelo, Del CaÑizo, Serna, Javier De la, Ardanaz, Maita, Marco, Victor, Collado, Rosa, Xicoy, Blanca, Sole, Francesc, Vallespi, Teresa
Format: Article
Language:English
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Summary:Abstract 1724 Cytogenetic abnormalities (CA) are the most important prognostic factor in patients with myelodysplastic syndromes (MDS). Monosomal karyotype (MK) defined as the presence of at least two autosomal monosomies or one monosomy plus other structural CA, has been associated with poor prognosis in acute myeloid leukemia (AML) but its significance in MDS remains unclear. The aim of our study was to analyze the prognostic impact of MK in adult patients with MDS and CA. Patients from Spanish Registry of MDS diagnosed with MDS by WHO 2008 criteria and with CA detected by conventional cytogenetics have been included in the study. Statistical analysis consisted of Kaplan-Meyer univariate analysis (UA) including all known variables associated with prognosis in MDS and a Cox-regression multivariate analysis (MA) in which we included only those variables with a P
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V118.21.1724.1724