Risk Factors Affecting Cardiac Left Ventricular Systolic and Diastolic Function and Hypertrophy in the Chronic Phase Post-Allogeneic Hematopietic Cell Transplantation

• Published in: Blood 2011-11, Vol.118 (21), p.2000-2000
• Main Authors: Nishimoto, Mitsutaka, Nakamae, Hirohisa, Nakane, Takahiko, Koh, Hideo, Hayashi, Yoshiki, Nakamae, Mika, Yoshida, Masahiro, Bingo, Masato, Okamura, Hiroshi, Aimoto, Mizuki, Manabe, Masahiro, Yoshimura, Takuro, Inaba, Akiko, Nanno, Satoshi, Hirose, Asao, Hagihara, Kiyoyuki, Nakao, Yoshitaka, Terada, Yoshiki, Hino, Masayuki
• Format: Article
• Language: English
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V118.21.2000.2000

Abstract 2000 The long-term survival rate after allogeneic hematopoietic cell transplantation (HCT) has been significantly improved over recent decades due to improvements in the HCT procedure. However, chronic complications such as cardiovascular disease have become increasingly evident and constitute a serious problem among long-term survivors after HCT. It is well-known that high-dose cyclophosphamide (CY) used for conditioning is one of the major causes of acute cardiotoxicity after HCT; however, it is still unclear which factors contribute to chronic cardiotoxicity. Although there is a possibility that chronic GVHD (cGVHD) causes cardiac tissue damage via cytokines such as IL-2, or TNF-alpha, it is unclear whether or not cGVHD influences cardiac function. In the present retrospective cohort study, we investigated which factors affected cardiac function and left ventricular hypertrophy (LVH) in the chronic phase after HCT. We examined left ventricular systolic and diastolic functions and LVH in patients who received HCT between April 2000 and March 2011 and survived for more than one year post-HCT. Only the patients who had undergone an echocardiographic examination before HCT were eligible for the study. We assessed left ventricular ejection fraction (LVEF) as a surrogate marker of LV systolic function and the early peak flow velocity/atrial peak flow velocity (E/A) as a surrogate marker of LV diastolic function using echocardiography. LVH after HCT was identified when the interventricular septal wall (IVS) and/or the posterior wall (PW) became more than 12 mm thick after HCT. We examined the factors that could have had some influence on cardiac function after HCT including age, sex, cumulative dose of anthracycline, use of high-dose CY in the conditioning, total body irradiation (TBI), intensity of conditioning regimen (myeloablative vs. reduced intensity conditioning), a history of hypertension, hemoglobin and serum ferritin levels. A total of 58 patients (25 males and 33 females) were eligible for participation in the study. The median age of enrolled patients was 46 years (range: 21–73). The median cumulative dose of anthracycline was 90 mg/m2 (0–431mg/m2). Forty-nine patients received myeloablative conditioning and 20 of these patients received myeloabative conditioning with TBI 12 Gy. Twenty-four patients were treated for cGVHD and 7 had a history of hypertension and 2 had an LVEF of less than 55% before HCT. Six had an LVEF of less than 55% at