Combined Analysis Using Visual and SUV-Based Quantitative Assessments Improves Predictive Value of Interim Positron Emission Tomography Scan in Diffuse Large B-Cell Lymphoma Treated with R-CHOP

Abstract 3690 Positron emission tomography (PET) has been identified as a useful tool for initial staging and end-of-therapy response assessment in patients with diffuse large B-cell lymphoma (DLBCL). However, the role of an interim PET to predict outcome is still controversial. This may be related...

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Published in:Blood 2012-11, Vol.120 (21), p.3690-3690
Main Authors: Yhim, Ho-Young, Lee, Na-Ri, Song, Eun-Kee, Jeon, So Yeon, Yim, Chang-Yeol, Han, Yeon-Hee, Sohn, Myung-Hee, Lee, Bohee, Kim, Jeong-A, Park, Young Ha, Choi, Woo Hee, Kim, Hee Sun, Kwak, Jae-Yong
Format: Article
Language:English
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Summary:Abstract 3690 Positron emission tomography (PET) has been identified as a useful tool for initial staging and end-of-therapy response assessment in patients with diffuse large B-cell lymphoma (DLBCL). However, the role of an interim PET to predict outcome is still controversial. This may be related that reliable criteria to interpret interim PET has not been established. Recently, Deauville five-point scale (5-PS) and standardized uptake value (SUV)-based analysis were proposed for the interpretation of interim PET. However, Deauville 5-PS might still be related to false positive results in some patients and SUV-based analysis not be suitable for patients with low baseline or high interim SUVmax. Therefore, the aim of this study was to investigate the prognostic implication of interim PET interpretation combining visual and SUV-based quantitative assessments in patients with DLBCL treated with R-CHOP chemotherapy. We consecutively enrolled newly diagnosed DLBCL patients, treated with R-CHOP chemotherapy and had the baseline PET data with 31 evaluable hypermetabolic lesion between 2006 and 2011 in two Korean institutions. Interim PET scan was performed after 3 or 4 cycles of R-CHOP, before 1 week of the next cycle. All PET assessment was performed by 2 nuclear medicine specialists at each institution, and the discrepancy of assessment was resolved by the agreement through discussion. Interim PET response was assessed by visual analysis using Deauville 5-PS and quantitative method based on SUVmax reduction rate. After using the receiver operating characteristics analysis, SUVmax reduction
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V120.21.3690.3690