Increased Local Disorder of DNA Methylation Forms the Basis of High Intra-Leukemic Epigenetic Heterogeneity and Enhances CLL Evolution

We recently demonstrated that genetic heterogeneity contributes to evolution and clinical outcome in chronic lymphocytic leukemia (CLL) (Landau et al., Cell 2013). As both genetic and epigenetic alterations contribute to the cellular phenotype and its fitness for selection, we hypothesized that hete...

Full description

Saved in:
Bibliographic Details
Published in:Blood 2013-11, Vol.122 (21), p.596-596
Main Authors: Landau, Dan-Avi, Clement, Kendell, Boyle, Patrick, Ziller, Michael, Stevenson, Kristen E., Kotliar, Dylan, Saksena, Gordon, Eng, M., Sougnez, Carrie, Zhang, Wandi, Ghandi, Mahmoud, Garraway, Levi, Gabriel, Stacey, Lander, Eric S., Brown, Jennifer R., Neuberg, Donna S., Hacohen, Nir, Getz, Gad, Meissner, Alexander, Wu, Catherine J.
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We recently demonstrated that genetic heterogeneity contributes to evolution and clinical outcome in chronic lymphocytic leukemia (CLL) (Landau et al., Cell 2013). As both genetic and epigenetic alterations contribute to the cellular phenotype and its fitness for selection, we hypothesized that heterogeneity in DNA methylation impacts leukemic evolution as well. We analyzed existing CLL methylation data (Kulis et al., Nat Gen 2012), and found higher heterogeneity in 450K arrays of 139 CLLs compared to 23 normal B cell samples, with a higher proportion of sites having intermediate levels of methylation (13.7% vs 10.7%, P
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V122.21.596.596