Detection of Multiple Double-Stranded DNA Viruses after Cord Blood Transplantation Is Frequent and Persistent

Background: DNA viral infections remain important causes of morbidity following cord blood transplantation (CBT). The cumulative incidence, risk factors, and kinetics of reactivation of multiple double-stranded (ds)DNA viruses after CBT are unknown. This lack of understanding limits development of s...

Full description

Saved in:
Bibliographic Details
Published in:Blood 2015-12, Vol.126 (23), p.3104-3104
Main Authors: Hill, Joshua A, Mayer, Bryan T, Xie, Hu, Leisenring, Wendy M, Milano, Filippo, Delaney, Colleen, Huang, Meei-Li, Stevens-Ayers, Terry L, Jerome, Keith R, Nichols, Garrett, Zerr, Danielle M, Schiffer, Joshua T, Boeckh, Michael
Format: Article
Language:English
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: DNA viral infections remain important causes of morbidity following cord blood transplantation (CBT). The cumulative incidence, risk factors, and kinetics of reactivation of multiple double-stranded (ds)DNA viruses after CBT are unknown. This lack of understanding limits development of strategies for broader prophylaxis. Methods: Weekly plasma samples through 100 days post-CBT were retrospectively tested by quantitative PCR for HHV-6B, HHV-6A, BK, adenovirus (ADV), and EBV; twice-weekly tests for CMV were performed prospectively. Children and adults with ≥1 year of follow up and availability of >60% of samples while alive, with
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V126.23.3104.3104