The Impact of Breastfeeding on the Childhood Acute Leukemia Risk Among Children Attending Alexandria University Children's Hospital

• Published in: Blood 2015-12, Vol.126 (23), p.3733-3733
• Main Authors: Massoud, Mohamed NZ, Hassab, Hoda MA, Ali, Aida M M, Mohamed, Doha N
• Format: Article
• Language: English
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood.V126.23.3733.3733

The present study was conducted to investigate the impact of breastfeeding on the risk of development of acute leukemia among children Admitted to Alexandria University Children's Hospital. A case control study included 134 ALL&AML cases & 134 matched controls for age & sex from the same family relatives to evaluate socioeconomic & genetic causes of the disease. The mothers were interviewed for the completion of interview format that included: duration & patterns of breastfeeding. lower proportion of acute leukemia cases 59.7% were exclusively breast-fed babies as compared to 89.6% of the control subjects. However, higher proportions of index children were either predominant breast-fed 19.4% or complementary-fed 10.4%. Nearly 10.4% were bottle-fed babies as compared to none of their controls. The differences between cases & controls as regards pattern of breast feeding were statistically significant where p0.0001*Bottle feeding1410.4002.5(2.1 - 2.9)*X2 = 19.12 P>0.0001*Duration of breastfeeding0-≤ 3 month21.700X2 =15.331 MC P=0.0001*AN-FEP=0.18=13.06 P=0.0003*X2=0.38 P=0.5373-≤ 6 month1714.232.27.6(2.1 - 33.8)*6-12 month1613.31712.71.260.6-2.8More than 12 month8570.811485.11-X2: Chi-Square test FEP: Fisher's Exact test -NA-: Not Applicable *significant at P≤0.0 No relevant confl