The Histochemical Study of Zinc Content in Granulocytes in Normal Adults and in Hematologic Disorders

Zinc in granulocytes was determined using a dithizone histochemical method. Investigations were performed in both bone marrow and in peripheral blood from ten healthy adults and in 62 patients with various hematologic disorders. In bone marrow, zinc appears in metamyelocytes. The amount increases wi...

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Bibliographic Details
Published in:Blood 1965-01, Vol.25 (1), p.56-62
Main Authors: Stanislaw, Szmigielski, Joanna, Litwin
Format: Article
Language:English
Subjects:
Blood
Bone Marrow Cells
Bone Marrow Diseases
Histology
Hodgkin Disease
Humans
Leukemia
Leukemia, Lymphoid
Leukemia, Myeloid
Leukocytes
Lymphocytes
Multiple Myeloma
Neutrophils
Zinc
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Summary:Zinc in granulocytes was determined using a dithizone histochemical method. Investigations were performed in both bone marrow and in peripheral blood from ten healthy adults and in 62 patients with various hematologic disorders. In bone marrow, zinc appears in metamyelocytes. The amount increases with maturation. In the granulocytes of peripheral blood, zinc values are about 30 per cent higher than in bone marrow. Zinc is significantly decreased in granulocytes in chronic granulocytic leukemia, acute myeloblastic leukemia, multiple myeloma and Hodgkin’s and increased in chronic lymphocytic leukemia and osteomyelosclerosis.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V25.1.56.56