BRIEF REPORT: Defective Synthesis of IgM Antibodies in Macroglobulinemia

Four patients with macroglobulinemia demonstrated an impaired ability to produce IgM antibody when stimulated with a relatively weak antigen, sheep cell stroma, but not with a more potent antigen, Brucellin. The explanation of this defect is unknown. It may be in part the cause of the greater-than-n...

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Bibliographic Details
Published in:Blood 1967-12, Vol.30 (6), p.767-771
Main Authors: PITTS, NEAL C., MCDUFFIE, FREDERIC C.
Format: Article
Language:English
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Summary:Four patients with macroglobulinemia demonstrated an impaired ability to produce IgM antibody when stimulated with a relatively weak antigen, sheep cell stroma, but not with a more potent antigen, Brucellin. The explanation of this defect is unknown. It may be in part the cause of the greater-than-normal infection rate seen in patients with macroglobulinemia.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V30.6.767.767