Lymphocyte Transformation Induced by Autologous Platelets in a Case of Thrombocytopenic Purpura

In a case of chronic thrombocytopenic purpura, significant lymphocyte transformation could be induced with autologous platelets as a stimulant. The reaction was not due to serum factors since it occurred when culture medium was supplemented either with autologous or pooled human serum. Controls excl...

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Bibliographic Details
Published in:Blood 1970-10, Vol.36 (4), p.421-427
Main Authors: Piessens, Willy F., Wybran, Joseph, Manaster, Joseph, Strijckmans, Pierre A.
Format: Article
Language:English
Subjects:
Aged
Antigens
Autoradiography
Blood Cell Count
Blood Platelets - immunology
Coombs Test
Culture Techniques
Diabetes Mellitus - etiology
DNA - biosynthesis
Female
Heart Failure - etiology
Humans
Hypertension - etiology
Lectins - pharmacology
Lymphocyte Activation
Lymphocytes - immunology
Melena - etiology
Osteoporosis - etiology
Purpura, Thrombocytopenic - complications
Purpura, Thrombocytopenic - immunology
Purpura, Thrombocytopenic - therapy
Spleen - pathology
Splenectomy
Thymidine - metabolism
Triamcinolone - adverse effects
Tritium
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Summary:In a case of chronic thrombocytopenic purpura, significant lymphocyte transformation could be induced with autologous platelets as a stimulant. The reaction was not due to serum factors since it occurred when culture medium was supplemented either with autologous or pooled human serum. Controls excluded nonspecific lymphocyte transformation. Modulation of normal platelet antigens by viral or chemical factors or adsorption of such factors on the platelet membrane could account for the observed reactions. However, since other auto-antibodies were demonstrated, the hypothesis of altered cellular „self-recognition“ mechanisms is tentatively proposed as an alternative explanation for this observation.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V36.4.421.421