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Blood group D antigen content of nucleated red cell precursors

The D antigen content of nucleated red cell precursors in human bone marrow was estimated using autoradiography and 125I-anti-D. D antigen first appeared in the pronormoblast, and the quantity of antigen progressively increased during red cell maturation. Maximal anti-D binding occurred on mature re...

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Bibliographic Details
Published in:Blood 1977-12, Vol.50 (6), p.981-986
Main Authors: Rearden, A, Masouredis, SP
Format: Article
Language:English
Online Access:Get full text
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Summary:The D antigen content of nucleated red cell precursors in human bone marrow was estimated using autoradiography and 125I-anti-D. D antigen first appeared in the pronormoblast, and the quantity of antigen progressively increased during red cell maturation. Maximal anti-D binding occurred on mature red blood cells. Pronormoblasts, basophilic normoblasts, polychromatophilic normoblasts, and orthochromatic normoblasts, respectively, had approximately 1/4, 1/2, 2/3, and 3/4 the quantity of antigen found on mature red cells. None of the other cell types were found in bone marrow labeled with anti-D.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V50.6.981.bloodjournal506981