Subsets of Malignant Lymphomas in Children Related to the Cell Phenotype

We studied the lymphomatous cells of 39 children presenting with the classical features of malignant lymphoma. Twenty-two had T lymphoblasts. We could classify these patients into three subsets: The T lymphoblasts from children group 1 displayed antigen(s) shared by a thymocyte subpopulation, had te...

Full description

Saved in:
Bibliographic Details
Published in:Blood 1979-11, Vol.54 (5), p.1058-1068
Main Authors: Bernard, Alain, Boumsell, Laurence, Bayle, Chantal, Richard, Yolande, Coppin, Hélène, Penit, Claude, Rouget, Pierre, Micheau, Christian, Clausse, Bernard, Gerard-Marchant, Rémy, Dausset, Jean, Lemerle, Jean
Format: Article
Language:English
Subjects:
Adolescent
Antilymphocyte Serum - pharmacology
B-Lymphocytes - classification
Cell Transformation, Neoplastic
Child
Child, Preschool
Epitopes
Female
Humans
Lymphoma - blood
Lymphoma - drug therapy
Male
Phenotype
Receptors, Antigen, B-Cell
Rosette Formation
T-Lymphocytes - classification
T-Lymphocytes - immunology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the lymphomatous cells of 39 children presenting with the classical features of malignant lymphoma. Twenty-two had T lymphoblasts. We could classify these patients into three subsets: The T lymphoblasts from children group 1 displayed antigen(s) shared by a thymocyte subpopulation, had terminal deoxynucleotidyl transferase (TDT), but no affinity for peanut agglutinin (PNA). The T lymphoblasts from children group 2 lacked the thymocyte antigen(s), had no TDT, but showed affinity for PNA. The T lymphoblasts from children group 3 displayed mature T-cell antigens, had no TDT, and no affinity for PNA. Children from the three groups were similar in terms of clinical presentation, age and sex distribution, and cell morphology; however patients from the three groups might have a different prognosis. Fourteen children had B lymphoblasts that, in half of the cases, had affinity for Helix pomatia agglutinin. Three patients had lymphoblasts lacking specific marker. Two of them had cells displaying an antigen found on common acute lymphoblastic leukemia cells and had TDT.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V54.5.1058.1058