Platelet Production After Administration of Antiplatelet Serum and 5-Fluorouracil

Although 5-fluorouracil induces relatively minimal thrombocytopenia in mice compared with antiplatelet serum, the ensuing rebound thrombocytosis is much greater. It also occurs several days later. Administration of 5-fluorouracil 24 hr after antiplatelet serum suppresses the increase in platelets pr...

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Bibliographic Details
Published in:Blood 1980-01, Vol.55 (1), p.164-166
Main Authors: Radley, J.M., Hodgson, G.S., Levin, J.
Format: Article
Language:English
Subjects:
Animals
Blood Platelets - drug effects
Blood Platelets - immunology
Blood Platelets - physiology
Female
Fluorouracil - administration & dosage
Fluorouracil - pharmacology
Growth
Immune Sera - administration & dosage
Immune Sera - pharmacology
Megakaryocytes - cytology
Mice
Mice, Inbred C57BL
Platelet Count
Thrombocytosis - chemically induced
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Summary:Although 5-fluorouracil induces relatively minimal thrombocytopenia in mice compared with antiplatelet serum, the ensuing rebound thrombocytosis is much greater. It also occurs several days later. Administration of 5-fluorouracil 24 hr after antiplatelet serum suppresses the increase in platelets produced by antiplatelet serum, while the subsequent thrombocytosis is indistinguishable from that produced by 5-flourouracil alone. It is concluded that the thrombocytosis that occurs after 5-flourouracil originates from a class of primitive stem cells, or early megakaryocyte precursors, which are not killed by the drug. Thrombocytosis occurring after antiplatelet serum is derived from more mature precursor cells, which are sensitive to 5-fluorouracil.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V55.1.164.164